Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas

29 Sept 2021

Abstract excerpt

It is unclear how loss-of-function germline mutations in the widely-expressed co-chaperone AIP, result in young-onset growth hormone secreting pituitary tumours. The RET receptor, uniquely co-expressed in somatotrophs with PIT1, induces apoptosis when unliganded, while RET supports cell survival when it is bound to its ligand. We demonstrate that at the plasma membrane, AIP is required to form a complex with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caveolin-1 and cellular processes
Share to Growth Hormone and Insulin-like Growth Factors
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34588620
DOI: 10.1038/s41388-021-02009-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomasPMID 34588620Read ↗

Molecular genetics of the aip gene in familial pituitary tumorigenesis.Semantic proximity Read ↗

Pituitary Tumors: Genetic and Molecular Factors Underlying Pathogenesis and Clinical BehaviorSemantic proximity Read ↗

Interaction of AIP with protein kinase A (cAMP-dependent protein kinase)Semantic proximity Read ↗

miR ‐34a is upregulated in AIP ‐mutated somatotropinomas and promotes octreotide resistanceSemantic proximity Read ↗

Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspectsSemantic proximity Read ↗

Risk category system to identify pituitary adenoma patients with AIP mutationsSemantic proximity Read ↗

Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene.Semantic proximity Read ↗

Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice.Semantic proximity Read ↗

The clinical, pathological, and genetic features of familial isolated pituitary adenomasSemantic proximity Read ↗

Integrated proteogenomic characterization across major histological types of pituitary neuroendocrine tumorsSemantic proximity Read ↗

Isolated familial somatotropinoma: 11q13-loh and gene/protein expression analysis suggests a possible involvement of aip also in non-pituitary tumorigenesisSemantic proximity Read ↗

cAMP-specific PDE4 phosphodiesterases and AIP in the pathogenesis of pituitary tumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.