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Article

Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL): from discovery to gene identification.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Jan 2000

Fukutake Toshio

Abstract excerpt

Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a single-gene disorder directly affecting the cerebral small blood vessels, that is caused by mutations in the HTRA1 gene encoding HtrA serine peptidase/protease 1 (HTRA1). CARASIL is the second known genetic form of ischemic, nonhypertensive, cerebral small-vessel disease with an identified gene, along with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dementia, Multi-Infarct

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Share to High-Temperature Requirement A Serine Peptidase 1

Share to Leukoencephalopathy, Progressive Multifocal

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Source

Identifiers

PMID: 21215656
DOI: 10.1016/j.jstrokecerebrovasdis.2010.11.008

Genes

HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Research trail→

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Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL): from discovery to gene identification.PMID 21215656Read ↗

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Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL).Semantic proximity Read ↗

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HTRA1-Related Cerebral Small Vessel Disease: A Review of the LiteratureSemantic proximity Read ↗

[Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL)].Semantic proximity Read ↗

Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease.Semantic proximity Read ↗

Hereditary cerebral small vessel diseases: a review.Semantic proximity Read ↗

HTRA1-related autosomal dominant cerebral small vessel disease.Semantic proximity Read ↗

[CARASIL: Identification of the clinical concept].Semantic proximity Read ↗

Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL): A challenging diagnosis and a rare multiple sclerosis mimic.Semantic proximity Read ↗

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Genetically Confirmed CARASIL: Case Report with Novel HTRA1 Mutation and Literature Review.Semantic proximity Read ↗

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