Article
CCDC102B confers risk of low vision and blindness in high myopia.
Nature communications - 3 May 2018
Hosoda Yoshikatsu, Yoshikawa Munemitsu, Miyake Masahiro, Tabara Yasuharu, Shimada Noriaki, Zhao Wanting, Oishi Akio, Nakanishi Hideo, Hata Masayuki, Akagi Tadamichi, Ooto Sotaro, Nagaoka Natsuko, Fang Yuxin, Ohno-Matsui Kyoko, Cheng Ching-Yu, Saw Seang Mei, Yamada Ryo, Matsuda Fumihiko, Tsujikawa Akitaka, Yamashiro Kenji
Abstract excerpt
The incidence of high myopia is increasing worldwide with myopic maculopathy, a complication of myopia, often progressing to blindness. Our two-stage genome-wide association study of myopic maculopathy identifies a susceptibility locus at rs11873439 in an intron of CCDC102B (P = 1.77 × 10-12 and Pcorr = 1.61 × 10-10). In contrast, this SNP is not significantly associated with myopia itself. The association...
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