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Article

SETD2 Is Recurrently Mutated in Whole-Exome Sequenced Canine Osteosarcoma.

Cancer research - 1 Jul 2018

Sakthikumar Sharadha, Elvers Ingegerd, Kim Jaegil, Arendt Maja L, Thomas Rachael, Turner-Maier Jason, Swofford Ross, Johnson Jeremy, Schumacher Steven E, Alföldi Jessica, Axelsson Erik, Couto C Guillermo, Kisseberth William C, Pettersson Mats E, Getz Gad, Meadows Jennifer R S, Modiano Jaime F, Breen Matthew, Kierczak Marcin, Forsberg-Nilsson Karin, Marinescu Voichita D, Lindblad-Toh Kerstin

Abstract excerpt

Osteosarcoma is a debilitating bone cancer that affects humans, especially children and adolescents. A homologous form of osteosarcoma spontaneously occurs in dogs, and its differential incidence observed across breeds allows for the investigation of tumor mutations in the context of multiple genetic backgrounds. Using whole-exome sequencing and dogs from three susceptible breeds (22 golden retrievers, 21...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29724721
DOI: 10.1158/0008-5472.CAN-17-3558

Genes

SETD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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