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Article

The ITGB6 gene: its role in experimental and clinical biology

6 Nov 2019

Abstract excerpt

Integrin αvβ6 is a membrane-spanning heterodimeric glycoprotein involved in wound healing and the pathogenesis of diseases including fibrosis and cancer. Therefore, it is of great clinical interest for us to understand the molecular mechanisms of its biology. As the limiting binding partner in the heterodimer, the β6 subunit controls αvβ6 expression and availability. Here we describe our understanding of the...

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PMID: 32550552
DOI: 10.1016/j.gene.2019.100023

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