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CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic niches

1 Mar 2013

Abstract excerpt

The stem cell niche provides a regulatory microenvironment for cells as diverse as totipotent embryonic stem cells to cancer stem cells (CSCs) which exhibit stem cell-like characteristics and have the capability of regenerating the bulk of tumor cells while maintaining self-renewal potential. The transmembrane glycoprotein CD44 is a common component of the stem cell niche and exists as a standard isoform (CD44s)...

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PMID: 23598979
DOI: 10.1177/1535370213480714

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