Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Phenotypic Cell-Binding Screen Identifies a Novel Compound Targeting Triple-Negative Breast Cancer.

ACS combinatorial science - 11 Jun 2018

Chen Luxi, Long Chao, Youn Jonghae, Lee Jiyong

Abstract excerpt

We describe a "phenotypic cell-binding screen" by which therapeutic candidate targeting cancer cells of a particular phenotype can be isolated without knowledge of drug targets. Chemical library beads are incubated with cancer cells of the phenotype of interest in the presence of cancer cells lacking the phenotype of interest, and then the beads bound to only cancer cells of the phenotype of interest are selected...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Apoptosis
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterografts

Share to Mice, Nude

Share to Neoplastic Stem Cells

Share to Small Molecule Libraries

Share to Triple Negative Breast Neoplasms

Source

Identifiers

PMID: 29718663
DOI: 10.1021/acscombsci.8b00026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Phenotypic Cell-Binding Screen Identifies a Novel Compound Targeting Triple-Negative Breast Cancer.PMID 29718663Read ↗

Phenotypic High-Throughput Screening Elucidates Target Pathway in Breast Cancer Stem Cell–Like CellsSemantic proximity Read ↗

Phenotypic screening reveals topoisomerase I as a breast cancer stem cell therapeutic target.Semantic proximity Read ↗

Novel application of the published kinase inhibitor set to identify therapeutic targets and pathways in triple negative breast cancer subtypes.Semantic proximity Read ↗

Evaluating Drug Response in 3D Triple Negative Breast Cancer Tumoroids with High Content Imaging and AnalysisSemantic proximity Read ↗

Phenotypic screening in cancer drug discovery - past, present and future.Semantic proximity Read ↗

Cell surface profiling with peptide libraries yields ligand arrays that classify breast tumor subtypesSemantic proximity Read ↗

From Virtual Screening to Cell Phenotype: 4-Thiazolidone Scaffolds Targeting LOXL2 in Breast Cancer.Semantic proximity Read ↗

A chemical genetics approach for the discovery of apoptosis inducers: from phenotypic cell based HTS assay and structure-activity relationship studies, to identification of potential anticancer agents and molecular targets.Semantic proximity Read ↗

Combining phenotypic and proteomic approaches to identify membrane targets in a 'triple negative' breast cancer cell type.Semantic proximity Read ↗

Mammosphere-forming cells from breast cancer cell lines as a tool for the identification of CSC-like- and early progenitor-targeting drugs.Semantic proximity Read ↗

Microscopy-based phenotypic monitoring of MDA-MB-231 spheroids allows the evaluation of phenotype-directed therapy.Semantic proximity Read ↗

The E-Morph Screening Assay: Phenotypic Screening for Estrogenic or Anti-estrogenic Compound Activities.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.