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Article

Combining phenotypic and proteomic approaches to identify membrane targets in a 'triple negative' breast cancer cell type.

Molecular cancer - 13 Feb 2013

Rust Steven, Guillard Sandrine, Sachsenmeier Kris, Hay Carl, Davidson Max, Karlsson Anders, Karlsson Roger, Brand Erin, Lowne David, Elvin John, Flynn Matt, Kurosawa Gene, Hollingsworth Robert, Jermutus Lutz, Minter Ralph

Abstract excerpt

BACKGROUND: The continued discovery of therapeutic antibodies, which address unmet medical needs, requires the continued discovery of tractable antibody targets. Multiple protein-level target discovery approaches are available and these can be used in combination to extensively survey relevant cell membranomes. In this study, the MDA-MB-231 cell line was selected for membranome survey as it is a 'triple negative'...

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Identifiers

PMID: 23406016
DOI: 10.1186/1476-4598-12-11
PMCID: PMC3582597

Genes

BCAM
EGFR

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