Article
geno2pheno[ngs-freq]: a genotypic interpretation system for identifying viral drug resistance using next-generation sequencing data.
Nucleic acids research - 2 Jul 2018
Döring Matthias, Büch Joachim, Friedrich Georg, Pironti Alejandro, Kalaghatgi Prabhav, Knops Elena, Heger Eva, Obermeier Martin, Däumer Martin, Thielen Alexander, Kaiser Rolf, Lengauer Thomas, Pfeifer Nico
Abstract excerpt
Identifying resistance to antiretroviral drugs is crucial for ensuring the successful treatment of patients infected with viruses such as human immunodeficiency virus (HIV) or hepatitis C virus (HCV). In contrast to Sanger sequencing, next-generation sequencing (NGS) can detect resistance mutations in minority populations. Thus, genotypic resistance testing based on NGS data can offer novel, treatment-relevant...
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