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[Disruption of leucyl aminopeptidase gene affects phenotypes and second metabolite production of Saccharopolyspora spinosa].

Wei sheng wu xue bao = Acta microbiologica Sinica - 14 Apr 2016

Yang Yan, Luo Lingen, Xu Miao, Xia Liqiu

Abstract excerpt

Objective: In order to investigate effects of leucyl aminopeptidase on mycelia morphology, growth rate, spinosad yield and protein expression in Saccharopolyspora spinosa by disrupting its encoding gene pepA and analyzing the characteristics of engineered S. spinosa. Methods: The pepA gene of S. spinosa was amplified based on the conserved sequence and cloned into Escherichia coli-Streptomyces shuttle vector...

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PMID: 29717853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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