Article
Novel AKT1 mutations associated with cell-cycle abnormalities in gastric carcinoma.
Personalized medicine - 1 Mar 2018
Ghatak Souvik, Lalnunhlimi Sylvine, Lalrohlui Freda, Pautu Jeremy L, Zohmingthanga John, Kunnumakkara Ajaikumar B, Kumar Nachimuthu Senthil
Abstract excerpt
AIM: The aim of this study is to identify the AKT1 gene mutation driven pathogenicity in gastric cancer for Mizo population. METHODS: 50 diffuse-type gastric tumors were analyzed for AKT1 exon 2 and 14 mutations. Cell-cycle aberration was analyzed in the AKT1-mutated samples and the stability of the protein as well as exonic splicing enhancer motifs were examined. RESULTS: The novel mutations, 15553T >A and...
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