Article
Association of low-activity ALDH2 and alcohol consumption with risk of esophageal cancer in Chinese adults: A population-based cohort study.
International journal of cancer - 1 Oct 2018
Yu Canqing, Guo Yu, Bian Zheng, Yang Ling, Millwood Iona Y, Walters Robin G, Chen Yiping, Chen Yan, Zhang Xi, Lei Yulong, Chen Junshi, Chen Zhengming, Lv Jun, Li Liming
Abstract excerpt
Existing evidence remains inconclusive as to how the association between inactive ALDH2 and esophageal cancer (EC) depends on alcohol consumption. The study is based on the China Kadoorie Biobank cohort, with 10 years follow-up of 0.5 million adults aged 30-79 years. ALDH2 activity was assessed by both self-reported flushing response and Glu504Lys (rs671 G > A) polymorphism. Among both male and female...
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