Article
Monitoring of clonal evolution of double C-KIT exon 17 mutations by Droplet Digital PCR in patients with core-binding factor acute myeloid leukemia.
Leukemia research - 1 Jun 2018
Tan Yanhong, Liu Zhuang, Wang Wenjun, Zhu Guiyang, Guo Jianli, Chen Xiuhua, Zheng Chaofeng, Xu Zhifang, Chang Jianmei, Ren Fanggang, Wang Hongwei
Abstract excerpt
C-KIT gene mutations result in the constitutive activation of tyrosine kinase activity, and greatly affect the pathogenesis and prognosis of core-binding factor acute myeloid leukemia (CBF-AML). C-KIT mutations are often found as single point mutations. However, the rate of double mutations has recently increased in AML patients. In this study, we detected six cases (18.8%) harboring double C-KIT exon17 mutations...
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