Article
Effects of genetic polymorphisms on the sulfation of dehydroepiandrosterone and pregnenolone by human cytosolic sulfotransferase SULT2A1.
Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Oct 2018
Abunnaja Maryam S, Alherz Fatemah A, El Daibani Amal A, Bairam Ahsan F, Rasool Mohammed I, Gohal Saud A, Kurogi Katsuhisa, Suiko Masahito, Sakakibara Yoichi, Liu Ming-Cheh
Abstract excerpt
The cytosolic sulfotransferase (SULT) SULT2A1 is known to mediate the sulfation of DHEA as well as some other hydroxysteroids such as pregnenolone. The present study was designed to investigate how genetic polymorphisms of the human SULT2A1 gene may affect the sulfation of DHEA and pregnenolone. Online databases were systematically searched to identify human SULT2A1 single nucleotide polymorphisms (SNPs). Of the...
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