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Article

What's the damage? The impact of pathogens on pathways that maintain host genome integrity.

Cell host & microbe - 12 Mar 2014

Weitzman Matthew D, Weitzman Jonathan B

Abstract excerpt

Maintaining genome integrity and transmission of intact genomes is critical for cellular, organismal, and species survival. Cells can detect damaged DNA, activate checkpoints, and either enable DNA repair or trigger apoptosis to eliminate the damaged cell. Aberrations in these mechanisms lead to somatic mutations and genetic instability, which are hallmarks of cancer. Considering the long history of host-microbe...

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Identifiers

PMID: 24629335
DOI: 10.1016/j.chom.2014.02.010
PMCID: PMC4501477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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