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Article

Infection Reveals a Modification of SIRT2 Critical for Chromatin Association

1 Apr 2018

Abstract excerpt

Sirtuin 2 is a nicotinamide-adenine-dinucleotide-dependent deacetylase that regulates cell processes such as carcinogenesis, cell cycle, DNA damage, and infection. Subcellular localization of SIRT2 is crucial for its function but is poorly understood. Infection with the bacterial pathogen Listeria monocytogenes, which relocalizes SIRT2 from the cytoplasm to the chromatin, provides an ideal stimulus for the...

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PMID: 29694890
DOI: 10.1016/j.celrep.2018.03.116

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