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Article

Restoration of chondrocytic phenotype on a two-dimensional micropatterned surface.

Biointerphases - 26 Mar 2015

Zhou Mi, Yuan Xiaofei, Yin Huabing, Gough Julie E

Abstract excerpt

Chondrocytes within mature cartilage reside in a 3D matrix and adopt a distinctive round morphology. A vast 2D-culture surface is well-known to induce chondrocyte dedifferentiation characterized by the loss of spherical morphology and ceased expression of chondrogenic markers. Methods to restore chondrogenesis so far only occur on a certain level producing varied cell subpopulations and inferior cartilage matrix;...

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Identifiers

PMID: 25720765
DOI: 10.1116/1.4913565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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