Article
Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms.
Developmental cell - 23 Apr 2018
Tan Kai Li, Haelterman Nele A, Kwartler Callie S, Regalado Ellen S, Lee Pei-Tseng, Nagarkar-Jaiswal Sonal, Guo Dong-Chuan, Duraine Lita, Wangler Michael F, Bamshad Michael J, Nickerson Deborah A, Lin Guang, Milewicz Dianna M, Bellen Hugo J
Abstract excerpt
Nuclei are actively positioned and anchored to the cytoskeleton via the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex. We identified mutations in the Parkin-like E3 ubiquitin ligase Ariadne-1 (Ari-1) that affect the localization and distribution of LINC complex members in Drosophila. ari-1 mutants exhibit nuclear clustering and morphology defects in larval muscles. We show that Ari-1 mono-ubiquitinates...
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