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Article

Copy number variations of DNA repair genes and the age-related cataract: Jiangsu Eye Study.

Investigative ophthalmology & visual science - 1 Feb 2013

Jiang Jin, Zhou Jing, Yao Yong, Zhu Rongrong, Liang Congkai, Jiang Shengqun, Yang Mei, Lu Yixiang, Xing Qian, Guan Huaijin

Abstract excerpt

PURPOSE: DNA damage is critical in the pathogenesis of age-related cataract (ARC). This study examined the association of copy number variations (CNVs) of DNA repair genes with susceptibility to ARC in the Han Chinese. METHODS: Study participants were from the population-based Jiangsu Eye Study, which includes 780 ARC patients and 525 controls. DNA was extracted from blood for copy number (CN) assays using...

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Identifiers

PMID: 23329665
DOI: 10.1167/iovs.12-10948

Genes

ARC
HSF4
WRN

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