Article
Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis.
Journal of psychiatry & neuroscience : JPN - 1 May 2018
Tomioka Yukiko, Numata Shusuke, Kinoshita Makoto, Umehara Hidehiro, Watanabe Shin-Ya, Nakataki Masahito, Iwayama Yoshimi, Toyota Tomoko, Ikeda Masashi, Yamamori Hidenaga, Shimodera Shinji, Tajima Atsushi, Hashimoto Ryota, Iwata Nakao, Yoshikawa Takeo, Ohmori Tetsuro
Abstract excerpt
BACKGROUND: Alterations in one-carbon metabolism have been associated with schizophrenia, and vitamin B6 is one of the key components in this pathway. METHODS: We first conducted a case-control study of serum pyridoxal levels and schizophrenia in a large Japanese cohort (n = 1276). Subsequently, we conducted a meta-analysis of association studies (n = 2125). Second, we investigated whether rs4654748, which was...
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