Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis

Abstract excerpt

Background: Alterations in one-carbon metabolism have been associated with schizophrenia, and vitamin B6 is one of the key components in this pathway. Methods: We first conducted a case–control study of serum pyridoxal levels and schizophrenia in a large Japanese cohort ( n = 1276). Subsequently, we conducted a meta-analysis of association studies ( n = 2125). Second, we investigated whether rs4654748, which was...

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