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Article

In vivo insertion pool sequencing identifies virulence factors in a complex fungal-host interaction.

PLoS biology - 1 Apr 2018

Uhse Simon, Pflug Florian G, Stirnberg Alexandra, Ehrlinger Klaus, von Haeseler Arndt, Djamei Armin

Abstract excerpt

Large-scale insertional mutagenesis screens can be powerful genome-wide tools if they are streamlined with efficient downstream analysis, which is a serious bottleneck in complex biological systems. A major impediment to the success of next-generation sequencing (NGS)-based screens for virulence factors is that the genetic material of pathogens is often underrepresented within the eukaryotic host, making...

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Identifiers

PMID: 29684023
DOI: 10.1371/journal.pbio.2005129
PMCID: PMC5912717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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