Article
Barcoded mutant library enables high-throughput functional genomics in a filamentous fungus.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 2026
Huberman Lori B, Villalobos-Escobedo José M, Skerker Jeffrey M, Shi Ran, Rico-Ramírez Adriana M, Adams Catharine A, Arkin Adam P, Deutschbauer Adam M, Glass N Louise
Abstract excerpt
Advances in sequencing technology enabling rapid and inexpensive whole-genome sequencing highlight how few genes are functionally characterized. This problem is particularly acute in filamentous fungi, where even in the best studied organisms upward of half of genes are poorly characterized or unannotated. High-throughput tools to identify gene function exist for single-celled organisms, like yeast and bacteria....
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