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Article

TEX11 Modulates Germ Cell Proliferation by Competing with Estrogen Receptor β for the Binding to HPIP

3 Mar 2012

Abstract excerpt

Klinefelter syndrome (KS), characterized by the presence of more than one X-chromosome in men, is a major genetic cause of male infertility. Germ cell degeneration in KS patients is thought to be the consequences of overexpression of some genes on the X-chromosome. However, the identity of these genes and the underlying mechanisms remain unclear. Testis-expressed 11 (TEX11) is an X-chromosome-encoded...

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PMID: 22383461
DOI: 10.1210/me.2011-1263

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