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Article

Natural biological variation of white matter microstructure is accentuated in Huntington's disease.

Human brain mapping - 1 Sept 2018

Gregory Sarah, Crawford Helen, Seunarine Kiran, Leavitt Blair, Durr Alexandra, Roos Raymund A C, Scahill Rachael I, Tabrizi Sarah J, Rees Geraint, Langbehn Douglas, Orth Michael

Abstract excerpt

Huntington's disease (HD) is a monogenic neurodegenerative disorder caused by a CAG-repeat expansion in the Huntingtin gene. Presence of this expansion signifies certainty of disease onset, but only partly explains age at which onset occurs. Genome-wide association studies have shown that naturally occurring genetic variability influences HD pathogenesis and disease onset. Investigating the influence of...

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Identifiers

PMID: 29682858
DOI: 10.1002/hbm.24191
PMCID: PMC6099203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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