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Article

Genetic variants in ATM, H2AFX and MRE11 genes and susceptibility to breast cancer in the polish population.

BMC cancer - 20 Apr 2018

Podralska Marta, Ziółkowska-Suchanek Iwona, Żurawek Magdalena, Dzikiewicz-Krawczyk Agnieszka, Słomski Ryszard, Nowak Jerzy, Stembalska Agnieszka, Pesz Karolina, Mosor Maria

Abstract excerpt

BACKGROUND: DNA damage repair is a complex process, which can trigger the development of cancer if disturbed. In this study, we hypothesize a role of variants in the ATM, H2AFX and MRE11 genes in determining breast cancer (BC) susceptibility. METHODS: We examined the whole sequence of the ATM kinase domain and estimated the frequency of founder mutations in the ATM gene (c.5932G > T, c.6095G > A, and...

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Source

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Identifiers

PMID: 29678143
DOI: 10.1186/s12885-018-4360-3
PMCID: PMC5910560

Genes

ATM
MRE11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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