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Article

Hepatitis C virus entry: beyond receptors

6 Mar 2012

Abstract excerpt

HCV is a blood-borne pathogen that affects approximately 3% of the global population and leads to progressive liver disease. Recent advances have identified an essential role for host cell molecules: tetraspanin CD81, scavenger receptor B1 and the tight junction proteins claudin-1 and occludin in HCV entry, suggesting a complex multi-step process. The conserved nature of this receptor-dependent step in the viral...

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PMID: 22392805
DOI: 10.1002/rmv.723

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