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Article

Amyloid Precursor Protein Dimerisation Reduces Neurite Outgrowth.

Molecular neurobiology - 1 Jan 2019

Luu Luan, Ciccotosto Giuseppe D, Vella Laura J, Cheng Lesley, Roisman Laila C, Multhaup Gerhard, Hill Andrew F, Munter Lisa-Marie, Cappai Roberto

Abstract excerpt

The amyloid precursor protein (APP) undergoes extensive metabolism, and its transport and proteolytic processing can be modulated by its ability to form a homodimer. We have investigated the functional consequences of stabilised APP dimer expression in cells by studying the engineered dimerisation of the APPL17C (residue 17 in Aβ sequence) construct, which is associated with a 30% increase in APP dimer...

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PMID: 29675574
DOI: 10.1007/s12035-018-1070-4

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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