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Article

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

The EMBO journal - 21 Mar 2007

Munter Lisa-Marie, Voigt Philipp, Harmeier Anja, Kaden Daniela, Gottschalk Kay E, Weise Christoph, Pipkorn Rüdiger, Schaefer Michael, Langosch Dieter, Multhaup Gerd

Abstract excerpt

Processing of the amyloid precursor protein (APP) by beta- and gamma-secretases leads to the generation of amyloid-beta (Abeta) peptides with varying lengths. Particularly Abeta42 contributes to cytotoxicity and amyloid accumulation in Alzheimer's disease (AD). However, the precise molecular mechanism of Abeta42 generation has remained unclear. Here, we show that an amino-acid motif GxxxG within the APP...

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Share to Amyloid beta-Peptides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17332749
DOI: 10.1038/sj.emboj.7601616
PMCID: PMC1829382

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.PMID 17332749Read ↗

Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif.Semantic proximity Read ↗

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Structural Determinant of β-Amyloid Formation: From Transmembrane Protein Dimerization to β-Amyloid AggregatesSemantic proximity Read ↗

Effects of gamma-secretase cleavage-region mutations on APP processing and Abeta formation: interpretation with sequential cleavage and alpha-helical model.Semantic proximity Read ↗

Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.Semantic proximity Read ↗

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Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex.Semantic proximity Read ↗

Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides.Semantic proximity Read ↗

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