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Article

Enabling multiplexed testing of pooled donor cells through whole-genome sequencing.

Genome medicine - 19 Apr 2018

Chan Yingleong, Chan Ying Kai, Goodman Daniel B, Guo Xiaoge, Chavez Alejandro, Lim Elaine T, Church George M

Abstract excerpt

We describe a method that enables the multiplex screening of a pool of many different donor cell lines. Our method accurately predicts each donor proportion from the pool without requiring the use of unique DNA barcodes as markers of donor identity. Instead, we take advantage of common single nucleotide polymorphisms, whole-genome sequencing, and an algorithm to calculate the proportions from the sequencing data....

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Identifiers

PMID: 29673390
DOI: 10.1186/s13073-018-0541-6
PMCID: PMC5909281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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