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Article

Computational framework for next-generation sequencing of heterogeneous viral populations using combinatorial pooling.

Bioinformatics (Oxford, England) - 1 Mar 2015

Skums Pavel, Artyomenko Alexander, Glebova Olga, Ramachandran Sumathi, Mandoiu Ion, Campo David S, Dimitrova Zoya, Zelikovsky Alex, Khudyakov Yury

Abstract excerpt

MOTIVATION: Next-generation sequencing (NGS) allows for analyzing a large number of viral sequences from infected patients, providing an opportunity to implement large-scale molecular surveillance of viral diseases. However, despite improvements in technology, traditional protocols for NGS of large numbers of samples are still highly cost and labor intensive. One of the possible cost-effective alternatives is...

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PMID: 25359889
DOI: 10.1093/bioinformatics/btu726

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