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Article

S‐Nitrosylation of Prostacyclin Synthase Instigates Nitrate Cross‐Tolerance In Vivo

19 Apr 2018

Abstract excerpt

Development of nitrate tolerance is a major drawback to nitrate therapy. Prostacyclin (PGI2) is a powerful vasodilator produced from prostaglandin (PGH2) by prostacyclin synthase (PGIS) in endothelial cells. This study aimed to determine the role of PGIS S‐nitrosylation in nitrate tolerance induced by nitroglycerin (GTN). In endothelial cells, GTN increased PGIS S‐nitrosylation and disturbed PGH2 metabolism,...

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PMID: 29672839
DOI: 10.1002/cpt.1094

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