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Differential RNA Sequence Requirement for Dengue Virus Replication in Mosquito and Mammalian Cells

13 Jun 2013

Abstract excerpt

Dengue virus cycles between mosquitoes and humans. Each host provides a different environment for viral replication, imposing different selective pressures. We identified a sequence in the dengue virus genome that is essential for viral replication in mosquito cells but not in mammalian cells. This sequence is located at the viral 3' untranslated region and folds into a small hairpin structure. A systematic...

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PMID: 23760236
DOI: 10.1128/jvi.00567-13

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