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Article

High pressure NMR reveals conformational perturbations by disease-causing mutations in amyloid β-peptide.

Chemical communications (Cambridge, England) - 1 May 2018

Rosenman David J, Clemente Nicolina, Ali Muhammad, García Angel E, Wang Chunyu

Abstract excerpt

Here we present the high pressure NMR characterization of Aβ42 and two Aβ40 variants with Alzheimer-causing mutations E22G and D23N. While chemical shifts only identified localized changes at ambient pressure compared with Aβ40, high pressure NMR revealed a common site with heightened pressure sensitivity at Q15, K16 and L17 in all three variants, which correlates to higher β-propensity at central hydrophobic...

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Source

Identifiers

PMID: 29670961
DOI: 10.1039/c8cc01674g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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