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Article

Familial Alzheimer's Disease-Related Mutations Differentially Alter Stability of Amyloid-Beta Aggregates.

The journal of physical chemistry letters - 16 Feb 2023

Rezaei-Ghaleh Nasrollah, Amininasab Mehriar, Giller Karin, Becker Stefan

Abstract excerpt

Amyloid-beta (Aβ) deposition as senile plaques is a pathological hallmark of Alzheimer's disease (AD). AD is characterized by a large level of heterogeneity in amyloid pathology, whose molecular origin is poorly understood. Here, we employ NMR spectroscopy and MD simulation at ambient and high pressures and investigate how AD-related mutations in Aβ peptide influence the stability of Aβ aggregates. The...

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PMID: 36734539
DOI: 10.1021/acs.jpclett.2c03729
PMCID: PMC9940190

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