MOMD Analysis of NMR Line Shapes from Aβ-Amyloid Fibrils: A New Tool for Characterizing Molecular Environments in Protein Aggregates.

Abstract excerpt

The microscopic-order-macroscopic-disorder (MOMD) approach for 2H NMR line shape analysis is applied to dry and hydrated 3-fold- and 2-fold-symmetric amyloid-Aβ40 fibrils and protofibrils of the D23N mutant. The methyl moieties of L17, L34, V36 (C-CD3), and M35 (S-CD3) serve as probes. Experimental 2H spectra acquired previously in the 147-310 K range are used. MOMD describes local probe motion as axial diffusion...

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