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Article

Bayesian reconstruction of transmission within outbreaks using genomic variants.

PLoS computational biology - 1 Apr 2018

De Maio Nicola, Worby Colin J, Wilson Daniel J, Stoesser Nicole

Abstract excerpt

Pathogen genome sequencing can reveal details of transmission histories and is a powerful tool in the fight against infectious disease. In particular, within-host pathogen genomic variants identified through heterozygous nucleotide base calls are a potential source of information to identify linked cases and infer direction and time of transmission. However, using such data effectively to model disease...

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PMID: 29668677
DOI: 10.1371/journal.pcbi.1006117
PMCID: PMC5927459

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