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Article

When are pathogen genome sequences informative of transmission events?

PLoS pathogens - 1 Feb 2018

Campbell Finlay, Strang Camilla, Ferguson Neil, Cori Anne, Jombart Thibaut

Abstract excerpt

Recent years have seen the development of numerous methodologies for reconstructing transmission trees in infectious disease outbreaks from densely sampled whole genome sequence data. However, a fundamental and as of yet poorly addressed limitation of such approaches is the requirement for genetic diversity to arise on epidemiological timescales. Specifically, the position of infected individuals in a...

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Identifiers

PMID: 29420641
DOI: 10.1371/journal.ppat.1006885
PMCID: PMC5821398

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