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Article

Inactivation of MAP3K7 in FOXD1-expressing cells results in loss of mesangial PDGFRΒ and juvenile kidney scarring.

American journal of physiology. Renal physiology - 1 Aug 2018

Karolak Michele J, Guay Justin A, Oxburgh Leif

Abstract excerpt

Transforming growth factor-β (TGFβ) plays a central role in renal scarring, controlling extracellular matrix deposition by interstitial cells and mesangial cells. TGFβ signals through Smad and mitogen-activated protein kinase (MAPK) pathways. To understand the role of MAPK in interstitial and mesangial cells, we genetically inactivated TGFβ-activated kinase-1 ( Map3k7) using Foxd1+/cre. Embryonic kidney...

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Source

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Identifiers

PMID: 29667914
DOI: 10.1152/ajprenal.00493.2017
PMCID: PMC6139526

Genes

FOXD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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