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Article

BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism

1 Oct 2009

Abstract excerpt

The iterative formation of nephrons during embryonic development relies on continual replenishment of progenitor cells throughout nephrogenesis. Defining molecular mechanisms that maintain and regulate this progenitor pool is essential to understanding nephrogenesis in developmental and regenerative contexts. Maintenance of nephron progenitors is absolutely dependent on BMP7 signaling, and Bmp7-null mice exhibit...

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PMID: 19793891
DOI: 10.1242/dev.036335

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