Article
Heterogeneity in Positive Predictive Value of RAS Mutations in Cytologically Indeterminate Thyroid Nodules.
Thyroid : official journal of the American Thyroid Association - 1 Jun 2018
Nabhan Fadi, Porter Kyle, Lupo Mark A, Randolph Gregory W, Patel Kepal N, Kloos Richard T
Abstract excerpt
BACKGROUND: RAS mutations are common in the available mutational analysis of cytologically indeterminate (Cyto-I) thyroid nodules. However, their reported positive predictive value (PPV) for cancer is widely variable. The reason for this variability is unknown, and it causes clinical management uncertainty. A systematic review was performed, evaluating the PPV for cancer in RAS mutation positive Cyto-I nodules,...
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