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Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma

17 Feb 2019

Abstract excerpt

Abstract The immune response to melanoma improves the survival in untreated patients and predicts the response to immune checkpoint blockade. Here, we report genetic and environmental predictors of the immune response in a large primary cutaneous melanoma cohort. Bioinformatic analysis of 703 tumor transcriptomes was used to infer immune cell infiltration and to categorize tumors into immune subgroups, which were...

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PMID: 30773503
DOI: 10.1158/0008-5472.can-18-2864

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