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Article

Silence as a way of niche adaptation: mecC-MRSA with variations in the accessory gene regulator (agr) functionality express kaleidoscopic phenotypes.

Scientific reports - 8 Sept 2020

Huber Charlotte, Stamm Ivonne, Ziebuhr Wilma, Marincola Gabriella, Bischoff Markus, Strommenger Birgit, Jaschkowitz Greta, Marciniak Tessa, Cuny Christiane, Witte Wolfgang, Doellinger Joerg, Schaudinn Christoph, Thürmer Andrea, Epping Lennard, Semmler Torsten, Lübke-Becker Antina, Wieler Lothar H, Walther Birgit

Abstract excerpt

Functionality of the accessory gene regulator (agr) quorum sensing system is an important factor promoting either acute or chronic infections by the notorious opportunistic human and veterinary pathogen Staphylococcus aureus. Spontaneous alterations of the agr system are known to frequently occur in human healthcare-associated S. aureus lineages. However, data on agr integrity and function are sparse regarding...

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Identifiers

PMID: 32901059
DOI: 10.1038/s41598-020-71640-4
PMCID: PMC7479134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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