Article
Does matching for SNPs in the MHC gamma block in 10/10 HLA-matched unrelated donor-recipient pairs undergoing allogeneic stem cell transplant improve outcomes?
Human immunology - 1 Jul 2018
Moyer Ann M, Hashmi Shahrukh K, Kroning Cynthia, De Goey Steven R, Patnaik Mrinal, Litzow Mark, Gastineau Dennis A, Hogan William J, Jacob Eapen K, Kreuter Justin D, Wakefield Laurie L, Gandhi Manish J
Abstract excerpt
BACKGROUND: Matching at the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci is important in donor selection for patients undergoing unrelated allogeneic hematopoietic stem cell transplantation (ASCT). Additional matching across the MHC gamma region may further improve outcomes. METHODS: The MHC gamma region was retrospectively genotyped in 66 adult recipients of ASCT and their 10/10 matched unrelated donors. A...
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