Article
pH-Signaling Transcription Factor AopacC Regulates Ochratoxin A Biosynthesis in Aspergillus ochraceus.
Journal of agricultural and food chemistry - 2 May 2018
Wang Yan, Liu Fei, Wang Liuqing, Wang Qi, Selvaraj Jonathan Nimal, Zhao Yueju, Wang Yun, Xing Fuguo, Liu Yang
Abstract excerpt
In Aspergillus and Penicillium species, an essential pH-response transcription factor pacC is involved in growth, pathogenicity, and toxigenicity. To investigate the connection between ochratoxin A (OTA) biosynthesis and ambient pH, the AopacC in Aspergillus ochraceus was functionally characterized using a loss-of-function mutant. The mycelium growth was inhibited under pH 4.5 and 10.0, while the sporulation...
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