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Article

Improving the genetic signature of prostate cancer, the somatic mutations.

Urologic oncology - 1 Jun 2018

Martinez-Gonzalez Luis Javier, Pascual Geler Manrique, Robles Fernandez Inmaculada, Cozar Jose Manuel, Lorente Jose Antonio, Alvarez Cubero Maria Jesus

Abstract excerpt

BACKGROUND: Somatic mutations have been related to the highest incidence of metastatic disease and different treatment responses. The molecular cause of prostate cancer (PC) is still unclear; however, its progression involves alterations in oncogenes and tumor suppressor genes as well as somatic mutations such as the ones in PIK3CA gene. A high percentage of PC is considered sporadic, which means that the damage...

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Source

Identifiers

PMID: 29650325
DOI: 10.1016/j.urolonc.2018.03.012

Genes

KIT
KRAS
BRAF
EGFR
PTEN

Variants

rs3822214
rs112445441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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