Article
Parkinson's Disease Associated α-Synuclein Familial Mutants Promote Dopaminergic Neuronal Death in Drosophila melanogaster.
ACS chemical neuroscience - 21 Nov 2018
Mohite Ganesh M, Dwivedi Saumya, Das Subhadeep, Kumar Rakesh, Paluri Sravya, Mehra Surabhi, Ruhela Neha, S Arunima, Jha Narendra Nath, Maji Samir K
Abstract excerpt
α-Synuclein (α-Syn) aggregation and amyloid formation are associated with loss of dopaminergic neurons in Parkinson's disease (PD). In addition, familial mutations in α-Syn are shown to be one of the definite causes of PD. Here we have extensively studied familial PD associated α-Syn G51D, H50Q, and E46K mutations using Drosophila model system. Our data showed that flies expressing α-Syn familial mutants have a...
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