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Article

Transient Scleraxis Overexpression Combined with Cyclic Strain Enhances Ligament Cell Differentiation

12 Apr 2018

Abstract excerpt

Efforts to generate tissue-engineered anterior cruciate ligament replacements are limited by a lack of methods to derive mature ligament cells. Viral overexpression of the tendon/ligament marker scleraxis (Scx) can drive cell differentiation; however, the use of viral vectors hampers translation to clinical use. In this study, C3H10T1/2 cells were transiently transfected with expression vectors containing the...

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PMID: 29644940
DOI: 10.1089/ten.tea.2017.0481

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