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Article

Emerging ideas: Evaluation of stem cells genetically modified with scleraxis to improve rotator cuff healing.

Clinical orthopaedics and related research - 1 Oct 2011

Gulotta Lawrence V, Rodeo Scott A

Abstract excerpt

BACKGROUND: Rotator cuffs heal with an interposed layer of scar tissue that makes repairs prone to failure. Cell-based biologic therapies have the potential to augment this healing process. Scleraxis (Scx) is a transcription factor that is involved in tendon development during embryogenesis, and...

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Identifiers

PMID: 21132407
DOI: 10.1007/s11999-010-1727-4
PMCID: PMC3171546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21132407-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Emerging ideas: Evaluation of stem cells genetically modified with scleraxis to improve rotator cuff healing.PMID 21132407Read ↗

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Scleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype.Semantic proximity Read ↗

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