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Article

Quantitative characterization of all single amino acid variants of a viral capsid-based drug delivery vehicle.

Nature communications - 11 Apr 2018

Hartman Emily C, Jakobson Christopher M, Favor Andrew H, Lobba Marco J, Álvarez-Benedicto Ester, Francis Matthew B, Tullman-Ercek Danielle

Abstract excerpt

Self-assembling proteins are critical to biological systems and industrial technologies, but predicting how mutations affect self-assembly remains a significant challenge. Here, we report a technique, termed SyMAPS (Systematic Mutation and Assembled Particle Selection), that can be used to characterize the assembly competency of all single amino acid variants of a self-assembling viral structural protein. SyMAPS...

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Identifiers

PMID: 29643335
DOI: 10.1038/s41467-018-03783-y
PMCID: PMC5895741

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